Clamp-On Ultrasonic Flow Monitoring in Tangential Flow Filtration Systems
Tangential Flow Filtration (TFF) is a critical downstream bioprocessing step used in the purification and concentration of biologics such as monoclonal antibodies, vaccines, and proteins. Precise monitoring and control of fluid flow during TFF is essential to ensure process efficiency, product quality, and membrane performance.
Application Requirements
Tangential Flow Filtration systems require precise and reliable flow measurement to maintain optimal performance.
Key requirements include:
• Non-invasive measurement to preserve sterility and avoid contamination in single-use or sanitary systems
• Accurate, real-time flow monitoring to ensure consistent recirculation and filtration efficiency
• No pressure drop or flow disruption to maintain stable operating conditions
• Compatibility with flexible tubing and single-use assemblies
• Seamless integration with control systems for automation and process monitoring
Additionally, the process must support continuous operation where:
• Fluid flows parallel to the filtration membrane
• Permeate is removed as waste or product
• Retentate is recirculated back into the feed stream
These requirements demand a flow measurement solution that is both precise and adaptable.
Process Solution
The Brooks Instrument BCU Series Clamp-On Ultrasonic Flow Meter provides aneffective solution for TFF applications.
In operation:
1. Fluid begins circulating through the TFF system
2. The BCU Series flow meter is clamped onto the tubing and measures flow non-invasively
3. The fluid flows parallel to the filtration membrane
4. Permeate is separated and collected
5. The remaining fluid is recirculated back into the feed stream
Key Advantages
Non-Invasive Ultrasonic Measurement
• Eliminates contact with process fluid
• Maintains sterility and reduces contamination risk
High Accuracy and Stability
• Provides reliable flow data for consistent filtration performance
EtherNet/IP™ Connectivity
• Enables real-time communication with control systems
• Supports automated process control
Ease of Installation
• Clamp-on design allows quick setup without process interruption
• Ideal for single-use and disposable systems
Benefits for TFF Applications
• Improved process control through continuous flow monitoring
• Reduced contamination risk with non-invasive sensing
• Enhanced operational flexibility and faster setup
• Consistent product quality and filtration performance
• Scalable solution for development through production
Accurate flow measurement is essential for maintaining efficiency and consistency in Tangential Flow Filtration processes. The Brooks Instrument BCU Series Clamp-On Ultrasonic Flow Meter delivers a non-invasive, reliable solution that meets the demanding requirements of biopharmaceutical manufacturing.
By combining ultrasonic technology with EtherNet/IP connectivity, the BCU Series enables improved process control, enhanced product quality, and greater operational efficiency.
